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CRABP1

GENERAL INFORMATION

Gene name

 CRABP1

Gene description

 Cellular retinoic acid binding protein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (thyroid gland)
GTEx:Group enriched (caudate, hypothalamus, spleen, thyroid gland)
FANTOM5:Group enriched (retina, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a group of tissues, including thyroid gland and squamous epithelia

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA017203
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hypothalamus, spleen, thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (retina, thyroid gland)

GENE INFORMATION

Gene name

 CRABP1 (HGNC Symbol)

Synonyms

 CRABP, CRABP-I, CRABPI, RBP5

Description

 Cellular retinoic acid binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 78340324 - 78348230

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166426 (version 83.38)

Entrez gene

 1381

UniProt

 P29762 (UniProt - Evidence at protein level)

neXtProt

 NX_P29762

Antibodypedia

 CRABP1 antibodies

PROTEIN BROWSER
CRABP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRABP1-001
ENSP00000299529
ENST00000299529
P29762 [Direct mapping]
Cellular retinoic acid-binding protein 1
F1T0F7 [Target identity:100%; Query identity:100%]
Cellular retinoic acid binding protein 1; Cellular retinoic acid-binding protein 1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001972 [retinoic acid binding]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0034653 [retinoic acid catabolic process]
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 137 aa
15.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.