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PRTG

GENERAL INFORMATION

Gene name

 PRTG

Gene description

 Protogenin

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (thyroid gland)
GTEx:Tissue enhanced (thyroid gland)
FANTOM5:Tissue enhanced (retina, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA032138
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina, thyroid gland)

GENE INFORMATION

Gene name

 PRTG (HGNC Symbol)

Synonyms

 FLJ25756, IGDCC5

Description

 Protogenin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 55611546 - 55743090

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166450 (version 83.38)

Entrez gene

 283659

UniProt

 Q2VWP7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q2VWP7

Antibodypedia

 PRTG antibodies

PROTEIN BROWSER
PRTG-001
PRTG-002
PRTG-004
PRTG-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRTG-001
ENSP00000373937
ENST00000389286
Q2VWP7 [Direct mapping]
Protogenin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
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 1150 aa
127.1 kDa 		Yes 1
PRTG-002
ENSP00000453160
ENST00000561465
H0YLD1 [Direct mapping]
Protogenin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 218 aa
24.6 kDa 		No 0
PRTG-004
ENSP00000453335
ENST00000561292
H0YLT7 [Direct mapping]
Protogenin; Protogenin homolog (Gallus gallus), isoform CRA_b
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 137 aa
15.2 kDa 		Yes 0
PRTG-005
ENSP00000452760
ENST00000558349
H0YKD6 [Direct mapping]
Protogenin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 22 aa
2.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.