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Most malignancies showed cases of moderate to strong nuclear positivity. Prostate, endometrial, renal, liver cancer and malignant carcinoid were mainly weakly stained or negative.
Most carcinomas were negative, or showed distinct nuclear staining in a fraction of the cells. Moderate to strong nuclear immunoreactivity was observed mainly in malignant lymphomas, melanomas and squamous cell carcinomas.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
P33993 [Direct mapping] DNA replication licensing factor MCM7
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P33993 [Direct mapping] DNA replication licensing factor MCM7
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
P33993 [Direct mapping] DNA replication licensing factor MCM7
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P33993 [Direct mapping] DNA replication licensing factor MCM7
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)