Expression of CCDC68 in cancer - Summary

GENERAL INFORMATION
Gene name	CCDC68
Gene description	Coiled-coil domain containing 68
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression, most abundant in gastrointestinal tract and immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA040865 , HPA048197
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (favourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040865	HPA048197

GENE INFORMATION
Gene name	CCDC68 (HGNC Symbol)
Synonyms	SE57-1
Description	Coiled-coil domain containing 68 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.2
Chromosome location (bp)	54901509 - 54959508
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166510 (version 83.38)
Entrez gene	80323
UniProt	Q9H2F9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2F9
Antibodypedia	CCDC68 antibodies

PROTEIN BROWSER

CCDC68-001	CCDC68-005	CCDC68-006	CCDC68-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC68-001 ENSP00000466690 ENST00000591504	Q9H2F9 [Direct mapping] Coiled-coil domain-containing protein 68 A0A024R2B9 [Target identity:100%; Query identity:100%] Coiled-coil domain containing 68, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	335 aa 38.9 kDa	No	0
CCDC68-005 ENSP00000466731 ENST00000592040	K7EN04 [Direct mapping] Coiled-coil domain-containing protein 68 Show all	Predicted intracellular proteins Show all		203 aa 23.8 kDa	No	0
CCDC68-006 ENSP00000337209 ENST00000337363	Q9H2F9 [Direct mapping] Coiled-coil domain-containing protein 68 A0A024R2B9 [Target identity:100%; Query identity:100%] Coiled-coil domain containing 68, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	335 aa 38.9 kDa	No	0
CCDC68-201 ENSP00000413406 ENST00000432185	Q9H2F9 [Direct mapping] Coiled-coil domain-containing protein 68 A0A024R2B9 [Target identity:100%; Query identity:100%] Coiled-coil domain containing 68, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	335 aa 38.9 kDa	No	0