Tissue expression of CLEC4E - Summary - The Human Protein Atlas

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CLEC4E

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CLEC4E
Gene description	C-type lectin domain family 4, member E
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix, bone marrow, spleen)
GTEx:	Tissue enhanced (lung, spleen)
FANTOM5:	Tissue enhanced (lung, lymph node)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA004935
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, bone marrow, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, lymph node)

GENE INFORMATION
Gene name	CLEC4E (HGNC Symbol)
Synonyms	CLECSF9, mincle
Description	C-type lectin domain family 4, member E (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8533305 - 8540963
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166523 (version 83.38)
Entrez gene	26253
UniProt	Q9ULY5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULY5
Antibodypedia	CLEC4E antibodies

PROTEIN BROWSER

CLEC4E-001	CLEC4E-004	CLEC4E-005	CLEC4E-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC4E-001 ENSP00000299663 ENST00000299663	Q9ULY5 [Direct mapping] C-type lectin domain family 4 member E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002292 [T cell differentiation involved in immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0038094 [Fc-gamma receptor signaling pathway] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] GO:0050715 [positive regulation of cytokine secretion] Show all	219 aa 25.1 kDa	No	1
CLEC4E-004 ENSP00000387737 ENST00000446457	F8WFA1 [Direct mapping] C-type lectin domain family 4 member E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	92 aa 10.5 kDa	No	1
CLEC4E-005 ENSP00000443034 ENST00000545274	F5H5X7 [Direct mapping] C-type lectin domain family 4 member E Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	174 aa 20 kDa	No	0
CLEC4E-006 ENSP00000443328 ENST00000537698	H0YGH9 [Direct mapping] C-type lectin domain family 4 member E Show all	Predicted intracellular proteins Show all		94 aa 10.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.