Expression of ZNF3 in cancer - Summary - The Human Protein Atlas

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ZNF3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF3
Gene description	Zinc finger protein 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

general nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA003719
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable), urothelial cancer (favourable) and lung cancer (favourable).
Melanoma p<0.001 Urothelial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003719

GENE INFORMATION
Gene name	ZNF3 (HGNC Symbol)
Synonyms	A8-51, FLJ20216, HF.12, KOX25, PP838, Zfp113
Description	Zinc finger protein 3 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100064033 - 100082548
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166526 (version 83.38)
Entrez gene	7551
UniProt	P17036 (UniProt - Evidence at protein level)
neXtProt	NX_P17036
Antibodypedia	ZNF3 antibodies

PROTEIN BROWSER

ZNF3-001	ZNF3-005	ZNF3-006	ZNF3-007	ZNF3-008	ZNF3-009	ZNF3-013	ZNF3-015	ZNF3-201	ZNF3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF3-001 ENSP00000299667 ENST00000299667	P17036 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0030154 [cell differentiation] GO:0042802 [identical protein binding] GO:0045321 [leukocyte activation] GO:0046872 [metal ion binding] Show all	446 aa 50.9 kDa	No	0
ZNF3-005 ENSP00000416088 ENST00000412947	C9JIW8 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	149 aa 17.3 kDa	No	0
ZNF3-006 ENSP00000399951 ENST00000413658	P17036 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0030154 [cell differentiation] GO:0042802 [identical protein binding] GO:0045321 [leukocyte activation] Show all	131 aa 14.6 kDa	No	0
ZNF3-007 ENSP00000388042 ENST00000428683	C9J5S8 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	185 aa 21.2 kDa	No	0
ZNF3-008 ENSP00000405970 ENST00000449785	C9J5S8 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	185 aa 21.2 kDa	No	0
ZNF3-009 ENSP00000394113 ENST00000441298	C9JK31 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	98 aa 11.6 kDa	No	0
ZNF3-013 ENSP00000292393 ENST00000292393	F8WA60 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.2 kDa	No	0
ZNF3-015 ENSP00000416686 ENST00000415068	C9JE35 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	104 aa 11.9 kDa	No	0
ZNF3-201 ENSP00000306372 ENST00000303915	P17036 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0030154 [cell differentiation] GO:0042802 [identical protein binding] GO:0045321 [leukocyte activation] GO:0046872 [metal ion binding] Show all	446 aa 50.9 kDa	No	0
ZNF3-202 ENSP00000415358 ENST00000424697	P17036 [Direct mapping] Zinc finger protein 3 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0030154 [cell differentiation] GO:0042802 [identical protein binding] GO:0045321 [leukocyte activation] GO:0046872 [metal ion binding] Show all	446 aa 50.9 kDa	No	0

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The Human Protein Atlas

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