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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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A2ML1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

A2ML1

Gene description

Alpha-2-macroglobulin-like 1

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (HMC-1, hTCEpi, SK-BR-3)
HPA (normal tissue):Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 2 antibodies.
HPA038847 , HPA038848
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA038847
HPA038848

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of squamous cell carcinomas and melanomas along with isolated cases in other cancers displayed moderate to strong cytoplasmic positivity. Remaining tumors were mainly negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of squamous cell carcinomas exhibited strong cytoplasmic immunoreactivity. A few cases of urothelial cancers showed moderate to strong staining in a fraction of cells. Remaining cancers were negative.

GENE INFORMATION

Gene name

A2ML1 (HGNC Symbol)

Synonyms

CPAMD9, FLJ25179

Description

Alpha-2-macroglobulin-like 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

8822472 - 8887001

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166535 (version 83.38)

Entrez gene

144568

UniProt

A8K2U0 (UniProt - Evidence at protein level)

neXtProt

NX_A8K2U0

Antibodypedia

A2ML1 antibodies

PROTEIN BROWSER

A2ML1-001
A2ML1-003
A2ML1-004
A2ML1-008
A2ML1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

A2ML1-001
ENSP00000299698
ENST00000299698
A8K2U0 [Direct mapping]
Alpha-2-macroglobulin-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030414 [peptidase inhibitor activity]
GO:0052548 [regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
1454 aa
161.1 kDa
Yes 0
A2ML1-003
ENSP00000443174
ENST00000541459
H0YGG5 [Direct mapping]
Alpha-2-macroglobulin-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
1004 aa
110.6 kDa
No 0
A2ML1-004
ENSP00000438292
ENST00000539547
A8K2U0 [Direct mapping]
Alpha-2-macroglobulin-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030414 [peptidase inhibitor activity]
GO:0052548 [regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
963 aa
106 kDa
No 0
A2ML1-008
ENSP00000440662
ENST00000536789
F5GYG7 [Direct mapping]
Alpha-2-macroglobulin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
81 aa
8.9 kDa
No 0
A2ML1-009
ENSP00000440057
ENST00000545692
F5GXP1 [Direct mapping]
Alpha-2-macroglobulin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
183 aa
20.2 kDa
No 0

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