Expression of A2ML1 in cancer - Summary - The Human Protein Atlas

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A2ML1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	A2ML1
Gene description	Alpha-2-macroglobulin-like 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (HMC-1, hTCEpi, SK-BR-3)
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA038847 , HPA038848
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038847	HPA038848

GENE INFORMATION
Gene name	A2ML1 (HGNC Symbol)
Synonyms	CPAMD9, FLJ25179
Description	Alpha-2-macroglobulin-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8822472 - 8887001
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166535 (version 83.38)
Entrez gene	144568
UniProt	A8K2U0 (UniProt - Evidence at protein level)
neXtProt	NX_A8K2U0
Antibodypedia	A2ML1 antibodies

PROTEIN BROWSER

A2ML1-001	A2ML1-003	A2ML1-004	A2ML1-008	A2ML1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
A2ML1-001 ENSP00000299698 ENST00000299698	A8K2U0 [Direct mapping] Alpha-2-macroglobulin-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0052548 [regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	1454 aa 161.1 kDa	Yes	0
A2ML1-003 ENSP00000443174 ENST00000541459	H0YGG5 [Direct mapping] Alpha-2-macroglobulin-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	1004 aa 110.6 kDa	No	0
A2ML1-004 ENSP00000438292 ENST00000539547	A8K2U0 [Direct mapping] Alpha-2-macroglobulin-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0052548 [regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	963 aa 106 kDa	No	0
A2ML1-008 ENSP00000440662 ENST00000536789	F5GYG7 [Direct mapping] Alpha-2-macroglobulin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.9 kDa	No	0
A2ML1-009 ENSP00000440057 ENST00000545692	F5GXP1 [Direct mapping] Alpha-2-macroglobulin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		183 aa 20.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.