Tissue expression of TK2 - Summary - The Human Protein Atlas

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TK2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TK2
Gene description	Thymidine kinase 2, mitochondrial
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041162
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

N/A

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TK2 (HGNC Symbol)
Synonyms	SCA31
Description	Thymidine kinase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Chromosome	16
Cytoband	q21
Chromosome location (bp)	66508003 - 66552544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166548 (version 83.38)
Entrez gene	7084
UniProt	O00142 (UniProt - Evidence at protein level)
neXtProt	NX_O00142
Antibodypedia	TK2 antibodies

PROTEIN BROWSER

TK2-001	TK2-002	TK2-003	TK2-004	TK2-005	TK2-006	TK2-008	TK2-009	TK2-014	TK2-016	TK2-017	TK2-019	TK2-020	TK2-201	TK2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TK2-001 ENSP00000414334 ENST00000451102	E5KNQ5 [Direct mapping] Mitochondrial thymidine kinase 2; Thymidine kinase 2, mitochondrial; Thymidine kinase 2, mitochondrial, isoform CRA_e Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	307 aa 35.4 kDa	No	0
TK2-002 ENSP00000433770 ENST00000527800	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	168 aa 20.3 kDa	No	0
TK2-003 ENSP00000434594 ENST00000525974	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	168 aa 20.3 kDa	No	0
TK2-004 ENSP00000435312 ENST00000527284	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	234 aa 27.6 kDa	No	0
TK2-005 ENSP00000407469 ENST00000417693	A0A0A0MSY7 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		289 aa 33.3 kDa	No	0
TK2-006 ENSP00000464313 ENST00000569718	J3QRP0 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 16.4 kDa	No	0
TK2-008 ENSP00000438143 ENST00000545043	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	240 aa 28.4 kDa	No	0
TK2-009 ENSP00000463560 ENST00000563369	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	168 aa 20.3 kDa	No	0
TK2-014 ENSP00000455187 ENST00000564917	H3BP77 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0009165 [nucleotide biosynthetic process] GO:0019206 [nucleoside kinase activity] Show all	282 aa 32.9 kDa	No	0
TK2-016 ENSP00000462341 ENST00000563478	J3KS73 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15.8 kDa	No	0
TK2-017 ENSP00000463326 ENST00000562484	J3QL12 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.7 kDa	No	0
TK2-019 ENSP00000462721 ENST00000561905	J3KSZ2 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.4 kDa	No	0
TK2-020 ENSP00000440898 ENST00000544898	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	265 aa 31 kDa	No	0
TK2-201 ENSP00000299697 ENST00000299697	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004137 [deoxycytidine kinase activity] GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006264 [mitochondrial DNA replication] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0009262 [deoxyribonucleotide metabolic process] GO:0016310 [phosphorylation] GO:0032042 [mitochondrial DNA metabolic process] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0046092 [deoxycytidine metabolic process] GO:0046104 [thymidine metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	265 aa 31 kDa	No	0
TK2-202 ENSP00000483833 ENST00000620035	O00142 [Direct mapping] Thymidine kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0016310 [phosphorylation] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0071897 [DNA biosynthetic process] Show all	247 aa 28.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.