Fields »
ABOUT
HELP
BLOG
MC4R

GENERAL INFORMATION

Gene name

 MC4R

Gene description

 Melanocortin 4 receptor

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, fallopian tube)
GTEx:Tissue enhanced (caudate, hypothalamus)
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA016719
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 MC4R

Synonyms

Description

 Melanocortin 4 receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]

Chromosome

 18

Cytoband

 q21.32

Chromosome location (bp)

 60371110 - 60372775

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166603 (version 83.38)

Entrez gene

 4160

UniProt

 P32245 (UniProt - Evidence at protein level)

neXtProt

 NX_P32245

Antibodypedia

 MC4R antibodies

PROTEIN BROWSER
MC4R-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MC4R-001
ENSP00000299766
ENST00000299766
P32245 [Direct mapping]
Melanocortin receptor 4
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0002024 [diet induced thermogenesis]
GO:0004930 [G-protein coupled receptor activity]
GO:0004977 [melanocortin receptor activity]
GO:0004980 [melanocyte-stimulating hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007631 [feeding behavior]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019222 [regulation of metabolic process]
GO:0030073 [insulin secretion]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032868 [response to insulin]
GO:0042923 [neuropeptide binding]
GO:0045780 [positive regulation of bone resorption]
GO:0060259 [regulation of feeding behavior]
GO:2000252 [negative regulation of feeding behavior]
GO:2000821 [regulation of grooming behavior]
Show all
 332 aa
36.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.