Expression of ATF7IP2 in cancer - Summary

GENERAL INFORMATION
Gene name	ATF7IP2
Gene description	Activating transcription factor 7 interacting protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression of varying intensity, highest expression in seminiferous ducts in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA041156 , HPA041228
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable), urothelial cancer (favourable) and breast cancer (favourable).
Liver cancer p<0.001 Urothelial cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041156	HPA041228

GENE INFORMATION
Gene name	ATF7IP2 (HGNC Symbol)
Synonyms	FLJ12668
Description	Activating transcription factor 7 interacting protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband
Chromosome location (bp)	10326434 - 10483638
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166669 (version 83.38)
Entrez gene	80063
UniProt	Q5U623 (UniProt - Evidence at protein level)
neXtProt	NX_Q5U623
Antibodypedia	ATF7IP2 antibodies

PROTEIN BROWSER

ATF7IP2-001	ATF7IP2-002	ATF7IP2-003	ATF7IP2-007	ATF7IP2-008	ATF7IP2-011	ATF7IP2-012	ATF7IP2-201	ATF7IP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATF7IP2-001 ENSP00000379808 ENST00000396560	Q5U623 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	682 aa 75.8 kDa	No	0
ATF7IP2-002 ENSP00000379807 ENST00000396559	Q5U623 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	543 aa 60.9 kDa	No	0
ATF7IP2-003 ENSP00000446119 ENST00000543967	B4DKH3 [Direct mapping] Activating transcription factor 7-interacting protein 2; cDNA FLJ57516, highly similar to Homo sapiens activating transcription factor 7 interacting protein 2 (ATF7IP2), mRNA Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	226 aa 24.9 kDa	No	0
ATF7IP2-007 ENSP00000461383 ENST00000562527	I3L4M8 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Show all		17 aa 2 kDa	No	0
ATF7IP2-008 ENSP00000457731 ENST00000562102	H3BUP1 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Show all		84 aa 9.1 kDa	No	0
ATF7IP2-011 ENSP00000454809 ENST00000569939	H3BNE6 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Show all		26 aa 3 kDa	No	0
ATF7IP2-012 ENSP00000456023 ENST00000569900	H3BR07 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Show all		74 aa 8 kDa	No	0
ATF7IP2-201 ENSP00000322811 ENST00000324570	Q5U623 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	543 aa 60.9 kDa	No	0
ATF7IP2-202 ENSP00000348799 ENST00000356427	Q5U623 [Direct mapping] Activating transcription factor 7-interacting protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	682 aa 75.8 kDa	No	0