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NGFRAP1

GENERAL INFORMATION

Gene name

 NGFRAP1

Gene description

 Nerve growth factor receptor (TNFRSF16) associated protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018886
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), renal cancer (favourable) and stomach cancer (unfavourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018886

GENE INFORMATION

Gene name

 NGFRAP1 (HGNC Symbol)

Synonyms

 Bex, BEX3, DXS6984E, HGR74, NADE

Description

 Nerve growth factor receptor (TNFRSF16) associated protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 X

Cytoband

 q22.2

Chromosome location (bp)

 103376340 - 103378077

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166681 (version 83.38)

Entrez gene

 27018

UniProt

 Q00994 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00994

Antibodypedia

 NGFRAP1 antibodies

PROTEIN BROWSER
NGFRAP1-001
NGFRAP1-002
NGFRAP1-003
NGFRAP1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NGFRAP1-001
ENSP00000361728
ENST00000372645
Q00994 [Direct mapping]
Protein BEX3
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Predicted intracellular proteins
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GO:0005123 [death receptor binding]
GO:0005163 [nerve growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0097190 [apoptotic signaling pathway]
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 111 aa
13 kDa 		No 0
NGFRAP1-002
ENSP00000354843
ENST00000361298
Q00994 [Direct mapping]
Protein BEX3
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0097190 [apoptotic signaling pathway]
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 101 aa
11.8 kDa 		No 0
NGFRAP1-003
ENSP00000361718
ENST00000372635
Q00994 [Direct mapping]
Protein BEX3
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0097190 [apoptotic signaling pathway]
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 111 aa
13 kDa 		No 0
NGFRAP1-004
ENSP00000361717
ENST00000372634
Q00994 [Direct mapping]
Protein BEX3
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Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0097190 [apoptotic signaling pathway]
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 101 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.