Expression of PLEKHA7 in cancer - Summary - The Human Protein Atlas

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PLEKHA7

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLEKHA7
Gene description	Pleckstrin homology domain containing, family A member 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA038610
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038610

GENE INFORMATION
Gene name	PLEKHA7 (HGNC Symbol)
Synonyms	DKFZp686M22243
Description	Pleckstrin homology domain containing, family A member 7 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband
Chromosome location (bp)	16778295 - 17014443
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166689 (version 83.38)
Entrez gene	144100
UniProt	Q6IQ23 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IQ23
Antibodypedia	PLEKHA7 antibodies

PROTEIN BROWSER

PLEKHA7-001	PLEKHA7-002	PLEKHA7-003	PLEKHA7-007	PLEKHA7-010	PLEKHA7-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA7-001 ENSP00000347883 ENST00000355661	Q6IQ23 [Direct mapping] Pleckstrin homology domain-containing family A member 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005915 [zonula adherens] GO:0030054 [cell junction] GO:0045218 [zonula adherens maintenance] GO:0070062 [extracellular exosome] GO:0070097 [delta-catenin binding] GO:0090136 [epithelial cell-cell adhesion] Show all	1121 aa 127.1 kDa	No	0
PLEKHA7-002 ENSP00000435389 ENST00000531066	E9PKC0 [Direct mapping] Pleckstrin homology domain-containing family A member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0030054 [cell junction] Show all	1271 aa 144.4 kDa	No	0
PLEKHA7-003 ENSP00000433467 ENST00000530489	H0YDE2 [Direct mapping] Pleckstrin homology domain-containing family A member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		753 aa 85.1 kDa	No	0
PLEKHA7-007 ENSP00000434812 ENST00000532079	E9PN45 [Direct mapping] Pleckstrin homology domain-containing family A member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 7.8 kDa	No	0
PLEKHA7-010 ENSP00000435806 ENST00000528376	E9PIK1 [Direct mapping] Pleckstrin homology domain-containing family A member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14.1 kDa	No	0
PLEKHA7-012 ENSP00000431455 ENST00000525581	E9PL74 [Direct mapping] Pleckstrin homology domain-containing family A member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 18.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.