Expression of CASC4 in cancer - Summary - The Human Protein Atlas

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CASC4

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CASC4
Gene description	Cancer susceptibility candidate 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA043015 , HPA049488
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043015	HPA049488

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	A majority of cancers showed moderate to strong cytoplasmic positivity in granular pattern. Colorectal cancers exhibited distinct extracellular positivity. Few cases of lymphomas and squamous cell carcinomas were negative.

GENE INFORMATION
Gene name	CASC4 (HGNC Symbol)
Synonyms	DKFZp459F1927, H63
Description	Cancer susceptibility candidate 4 (HGNC Symbol)
Entrez gene summary	The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	44288729 - 44415758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166734 (version 83.38)
Entrez gene	113201
UniProt	Q6P4E1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P4E1
Antibodypedia	CASC4 antibodies

PROTEIN BROWSER

CASC4-001	CASC4-002	CASC4-006	CASC4-009	CASC4-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASC4-001 ENSP00000299957 ENST00000299957	Q6P4E1 [Direct mapping] Protein CASC4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] Show all	436 aa 49.5 kDa	No	0
CASC4-002 ENSP00000335063 ENST00000345795	Q6P4E1 [Direct mapping] Protein CASC4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] Show all	380 aa 43.3 kDa	No	0
CASC4-006 ENSP00000453703 ENST00000559222	H0YMR0 [Direct mapping] Protein CASC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	113 aa 13.5 kDa	No	0
CASC4-009 ENSP00000453465 ENST00000558847	H0YM51 [Direct mapping] Protein CASC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.8 kDa	No	0
CASC4-011 ENSP00000452833 ENST00000561305	H0YKJ7 [Direct mapping] Protein CASC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.