Expression of AGBL1 in cancer - Summary - The Human Protein Atlas

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AGBL1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	AGBL1
Gene description	ATP/GTP binding protein-like 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (lung, skeletal muscle)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	AGBL1 (HGNC Symbol)
Synonyms	CCP4, FLJ32310
Description	ATP/GTP binding protein-like 1 (HGNC Symbol)
Entrez gene summary	Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]
Chromosome	15
Cytoband	q25.3
Chromosome location (bp)	86141996 - 87029052
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166748 (version 83.38)
Entrez gene	123624
UniProt	Q96MI9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MI9
Antibodypedia	AGBL1 antibodies

PROTEIN BROWSER

AGBL1-001	AGBL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGBL1-001 ENSP00000413001 ENST00000441037	Q96MI9 [Direct mapping] Cytosolic carboxypeptidase 4 Show all	Enzymes Peptidases Metallopeptidases THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0015631 [tubulin binding] GO:0035609 [C-terminal protein deglutamylation] GO:0035610 [protein side chain deglutamylation] Show all	1066 aa 120.3 kDa	No	0
AGBL1-201 ENSP00000397173 ENST00000421325	J3KQF5 [Direct mapping] Cytosolic carboxypeptidase 4 Show all	THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005488 [binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	1032 aa 116.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.