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PLIN1

GENERAL INFORMATION

Gene name

 PLIN1

Gene description

 Perilipin 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (breast cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA024299 , CAB033821 , CAB037333
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024299
CAB033821
CAB037333

GENE INFORMATION

Gene name

 PLIN1 (HGNC Symbol)

Synonyms

 PLIN

Description

 Perilipin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 89664365 - 89679427

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166819 (version 83.38)

Entrez gene

 5346

UniProt

 O60240 (UniProt - Evidence at protein level)

neXtProt

 NX_O60240

Antibodypedia

 PLIN1 antibodies

PROTEIN BROWSER
PLIN1-001
PLIN1-003
PLIN1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLIN1-001
ENSP00000300055
ENST00000300055
O60240 [Direct mapping]
Perilipin-1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0006629 [lipid metabolic process]
GO:0008289 [lipid binding]
GO:0019433 [triglyceride catabolic process]
GO:0044281 [small molecule metabolic process]
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 522 aa
56 kDa 		No 0
PLIN1-003
ENSP00000402167
ENST00000430628
O60240 [Direct mapping]
Perilipin-1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0006629 [lipid metabolic process]
GO:0008289 [lipid binding]
GO:0019433 [triglyceride catabolic process]
GO:0044281 [small molecule metabolic process]
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 522 aa
56 kDa 		No 0
PLIN1-005
ENSP00000453426
ENST00000560330
H0YM16 [Direct mapping]
Perilipin-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 73 aa
7.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.