Expression of NAV2 in cancer - Summary - The Human Protein Atlas

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NAV2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NAV2
Gene description	Neuron navigator 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SH-SY5Y)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA011755 , HPA011891
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011755	HPA011891

GENE INFORMATION
Gene name	NAV2 (HGNC Symbol)
Synonyms	FLJ10633, FLJ11030, FLJ23707, HELAD1, KIAA1419, POMFIL2, RAINB1
Description	Neuron navigator 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	p15.1
Chromosome location (bp)	19350724 - 20121598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166833 (version 83.38)
Entrez gene	89797
UniProt	Q8IVL1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVL1
Antibodypedia	NAV2 antibodies

PROTEIN BROWSER

NAV2-001	NAV2-002	NAV2-003	NAV2-005	NAV2-006	NAV2-008	NAV2-009	NAV2-201	NAV2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAV2-001 ENSP00000379396 ENST00000396087	Q8IVL1 [Direct mapping] Neuron navigator 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003025 [regulation of systemic arterial blood pressure by baroreceptor feedback] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005614 [interstitial matrix] GO:0005654 [nucleoplasm] GO:0007399 [nervous system development] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0007626 [locomotory behavior] GO:0008152 [metabolic process] GO:0008201 [heparin binding] GO:0021554 [optic nerve development] GO:0021563 [glossopharyngeal nerve development] GO:0021564 [vagus nerve development] Show all	2488 aa 268.2 kDa	No	0
NAV2-002 ENSP00000379394 ENST00000396085	Q8IVL1 [Direct mapping] Neuron navigator 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0008152 [metabolic process] Show all	2432 aa 261.7 kDa	No	0
NAV2-003 ENSP00000309577 ENST00000349880	Q8IVL1 [Direct mapping] Neuron navigator 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0008152 [metabolic process] Show all	2429 aa 261.4 kDa	No	0
NAV2-005 ENSP00000437316 ENST00000533917	Q8IVL1 [Direct mapping] Neuron navigator 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0008152 [metabolic process] Show all	1493 aa 161.9 kDa	No	0
NAV2-006 ENSP00000437136 ENST00000525322	E9PNV5 [Direct mapping] Neuron navigator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] Show all	816 aa 85.7 kDa	No	0
NAV2-008 ENSP00000353871 ENST00000360655	Q8IVL1 [Direct mapping] Neuron navigator 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0008152 [metabolic process] Show all	2365 aa 255 kDa	No	0
NAV2-009 ENSP00000431276 ENST00000530408	E9PLU3 [Direct mapping] Neuron navigator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] Show all	160 aa 17.1 kDa	No	0
NAV2-201 ENSP00000435395 ENST00000527559	A0A0A0MTE8 [Direct mapping] Neuron navigator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	2489 aa 268.3 kDa	No	0
NAV2-202 ENSP00000443489 ENST00000540292	A0A0A0MTL4 [Direct mapping] Neuron navigator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	2433 aa 261.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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