Expression of GPR182 in cancer - Summary

GENERAL INFORMATION
Gene name	GPR182
Gene description	G protein-coupled receptor 182
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (RH-30)
HPA (normal tissue):	Tissue enhanced (spleen, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High expression in endothelial cells and interclated discs in heart. Additional expression in sinusoids, spleen.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA027037
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA027037

GENE INFORMATION
Gene name	GPR182 (HGNC Symbol)
Synonyms	ADMR, AM-R, G10D, hrhAMR
Description	G protein-coupled receptor 182 (HGNC Symbol)
Entrez gene summary	Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	56994446 - 56998441
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166856 (version 83.38)
Entrez gene	11318
UniProt	O15218 (UniProt - Evidence at transcript level)
neXtProt	NX_O15218
Antibodypedia	GPR182 antibodies

PROTEIN BROWSER

GPR182-001	GPR182-002	GPR182-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR182-001 ENSP00000300098 ENST00000300098	O15218 [Direct mapping] G-protein coupled receptor 182 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001605 [adrenomedullin receptor activity] GO:0001666 [response to hypoxia] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] Show all	404 aa 45.3 kDa	No	7
GPR182-002 ENSP00000487111 ENST00000556850	A0A0D9SG31 [Direct mapping] G-protein-coupled receptor 182 Show all	Predicted intracellular proteins Show all		55 aa 5.6 kDa	No	0
GPR182-201 ENSP00000486086 ENST00000622922	Q7Z4H2 [Direct mapping] G-protein-coupled receptor 182; HBcAg-binding protein Show all	Predicted intracellular proteins Show all		196 aa 21.5 kDa	No	0