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XRCC6BP1

GENERAL INFORMATION

Gene name

 XRCC6BP1

Gene description

 XRCC6 binding protein 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA035804
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035804

GENE INFORMATION

Gene name

 XRCC6BP1 (HGNC Symbol)

Synonyms

 KUB3

Description

 XRCC6 binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q14.1

Chromosome location (bp)

 57941541 - 57957269

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166896 (version 83.38)

Entrez gene

 91419

UniProt

 Q9Y6H3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6H3

Antibodypedia

 XRCC6BP1 antibodies

PROTEIN BROWSER
XRCC6BP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRCC6BP1-001
ENSP00000300145
ENST00000300145
Q9Y6H3 [Direct mapping]
Mitochondrial inner membrane protease ATP23 homolog
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0004677 [DNA-dependent protein kinase activity]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006468 [protein phosphorylation]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
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 246 aa
28.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.