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STX3

GENERAL INFORMATION

Gene name

 STX3

Gene description

 Syntaxin 3

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Nuclear staining viewed as off target and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA002191 , HPA069176
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 STX3 (HGNC Symbol)

Synonyms

 STX3A

Description

 Syntaxin 3 (HGNC Symbol)

Entrez gene summary

 The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59713456 - 59805882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166900 (version 83.38)

Entrez gene

 6809

UniProt

 Q13277 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13277

Antibodypedia

 STX3 antibodies

PROTEIN BROWSER
STX3-001
STX3-003
STX3-004
STX3-006
STX3-007
STX3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STX3-001
ENSP00000338562
ENST00000337979
Q13277 [Direct mapping]
Syntaxin-3
Q53YE2 [Target identity:100%; Query identity:100%]
Syntaxin 3A; Syntaxin 3A, isoform CRA_c; cDNA FLJ43672 fis, clone SYNOV4007671, highly similar to Syntaxin-3; cDNA FLJ78704, highly similar to Homo sapiens syntaxin 3A (STX3A), mRNA; cDNA, FLJ93356, Homo sapiens syntaxin 3A (STX3A), mRNA
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005773 [vacuole]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0016192 [vesicle-mediated transport]
GO:0016324 [apical plasma membrane]
GO:0030027 [lamellipodium]
GO:0030141 [secretory granule]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0042581 [specific granule]
GO:0042582 [azurophil granule]
GO:0043005 [neuron projection]
GO:0045785 [positive regulation of cell adhesion]
GO:0048278 [vesicle docking]
GO:0050544 [arachidonic acid binding]
GO:0050921 [positive regulation of chemotaxis]
GO:0060291 [long-term synaptic potentiation]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 289 aa
33.2 kDa 		No 1
STX3-003
ENSP00000431386
ENST00000528805
A0A0C4DGE4 [Direct mapping]
Syntaxin-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0016192 [vesicle-mediated transport]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
 204 aa
23.2 kDa 		No 1
STX3-004
ENSP00000433248
ENST00000529177
Q13277 [Direct mapping]
Syntaxin-3
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005773 [vacuole]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0016192 [vesicle-mediated transport]
GO:0016324 [apical plasma membrane]
GO:0030027 [lamellipodium]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0042581 [specific granule]
GO:0042582 [azurophil granule]
GO:0043005 [neuron projection]
GO:0045785 [positive regulation of cell adhesion]
GO:0048278 [vesicle docking]
GO:0050544 [arachidonic acid binding]
GO:0050921 [positive regulation of chemotaxis]
GO:0070062 [extracellular exosome]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 277 aa
32 kDa 		No 0
STX3-006
ENSP00000434836
ENST00000530221
E9PN33 [Direct mapping]
Syntaxin-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
 76 aa
8.5 kDa 		No 1
STX3-007
ENSP00000487790
ENST00000633708
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
Show all
 287 aa
32.9 kDa 		No 1
STX3-201
ENSP00000300150
ENST00000300150
F8W9Y0 [Direct mapping]
Syntaxin-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0016192 [vesicle-mediated transport]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
 258 aa
29.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.