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MRPL16

GENERAL INFORMATION

Gene name

 MRPL16

Gene description

 Mitochondrial ribosomal protein L16

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA054133
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054133

GENE INFORMATION

Gene name

 MRPL16 (HGNC Symbol)

Synonyms

 FLJ20484, PNAS-111

Description

 Mitochondrial ribosomal protein L16 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59806135 - 59810872

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166902 (version 83.38)

Entrez gene

 54948

UniProt

 Q9NX20 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NX20

Antibodypedia

 MRPL16 antibodies

PROTEIN BROWSER
MRPL16-001
MRPL16-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL16-001
ENSP00000300151
ENST00000300151
Q9NX20 [Direct mapping]
39S ribosomal protein L16, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 251 aa
28.4 kDa 		No 0
MRPL16-004
ENSP00000436592
ENST00000534340
E9PI14 [Direct mapping]
39S ribosomal protein L16, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
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 86 aa
9.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.