Expression of NYAP1 in cancer - Summary - The Human Protein Atlas

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NYAP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NYAP1
Gene description	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (HUVEC TERT2, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS, testis and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA022251
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022251

GENE INFORMATION
Gene name	NYAP1 (HGNC Symbol)
Synonyms	C7orf51, FLJ37538, KIAA1486L
Description	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100483927 - 100494799
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166924 (version 83.38)
Entrez gene	222950
UniProt	Q6ZVC0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZVC0
Antibodypedia	NYAP1 antibodies

PROTEIN BROWSER

NYAP1-001	NYAP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NYAP1-001 ENSP00000300179 ENST00000300179	Q6ZVC0 [Direct mapping] Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0048812 [neuron projection morphogenesis] Show all	841 aa 87.9 kDa	No	0
NYAP1-002 ENSP00000394424 ENST00000454988	C9JS30 [Direct mapping] Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 Show all	Predicted intracellular proteins Show all	GO:0005622 [intracellular] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0048812 [neuron projection morphogenesis] Show all	785 aa 81.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.