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The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3 A0A024R5Z3 [Target identity:100%; Query identity:100%] Mothers against decapentaplegic homolog
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Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001707 [mesoderm formation] GO:0001756 [somitogenesis] GO:0001889 [liver development] GO:0001933 [negative regulation of protein phosphorylation] GO:0001947 [heart looping] GO:0002076 [osteoblast development] GO:0002520 [immune system development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0007369 [gastrulation] GO:0007492 [endoderm development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0009880 [embryonic pattern specification] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010694 [positive regulation of alkaline phosphatase activity] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016202 [regulation of striated muscle tissue development] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030308 [negative regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030501 [positive regulation of bone mineralization] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0030878 [thyroid gland development] GO:0031053 [primary miRNA processing] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032731 [positive regulation of interleukin-1 beta production] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032916 [positive regulation of transforming growth factor beta3 production] GO:0032924 [activin receptor signaling pathway] GO:0033689 [negative regulation of osteoblast proliferation] GO:0035326 [enhancer binding] GO:0035413 [positive regulation of catenin import into nucleus] GO:0035556 [intracellular signal transduction] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042110 [T cell activation] GO:0042177 [negative regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043234 [protein complex] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0046982 [protein heterodimerization activity] GO:0048340 [paraxial mesoderm morphogenesis] GO:0048589 [developmental growth] GO:0048617 [embryonic foregut morphogenesis] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050678 [regulation of epithelial cell proliferation] GO:0050728 [negative regulation of inflammatory response] GO:0050776 [regulation of immune response] GO:0050821 [protein stabilization] GO:0050927 [positive regulation of positive chemotaxis] GO:0051098 [regulation of binding] GO:0051496 [positive regulation of stress fiber assembly] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060039 [pericardium development] GO:0060290 [transdifferentiation] GO:0060395 [SMAD protein signal transduction] GO:0061045 [negative regulation of wound healing] GO:0070306 [lens fiber cell differentiation] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0001933 [negative regulation of protein phosphorylation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0031053 [primary miRNA processing] GO:0031625 [ubiquitin protein ligase binding] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032924 [activin receptor signaling pathway] GO:0035326 [enhancer binding] GO:0035413 [positive regulation of catenin import into nucleus] GO:0035556 [intracellular signal transduction] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043130 [ubiquitin binding] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050821 [protein stabilization] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0001933 [negative regulation of protein phosphorylation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0031053 [primary miRNA processing] GO:0031625 [ubiquitin protein ligase binding] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032924 [activin receptor signaling pathway] GO:0035326 [enhancer binding] GO:0035413 [positive regulation of catenin import into nucleus] GO:0035556 [intracellular signal transduction] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043130 [ubiquitin binding] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050821 [protein stabilization] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0001933 [negative regulation of protein phosphorylation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0031053 [primary miRNA processing] GO:0031625 [ubiquitin protein ligase binding] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032924 [activin receptor signaling pathway] GO:0035326 [enhancer binding] GO:0035413 [positive regulation of catenin import into nucleus] GO:0035556 [intracellular signal transduction] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043130 [ubiquitin binding] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050821 [protein stabilization] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly]