Expression of MAP1A in cancer - Summary

GENERAL INFORMATION
Gene name	MAP1A
Gene description	Microtubule-associated protein 1A
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (U-87 MG)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression most abundant in neuronal cells, Purkinje cells and subset of cells in molecular layer of cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA039063 , HPA039064
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable), urothelial cancer (unfavourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001 Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039063	HPA039064

GENE INFORMATION
Gene name	MAP1A (HGNC Symbol)
Synonyms	MAP1L
Description	Microtubule-associated protein 1A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43510958 - 43531620
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166963 (version 83.38)
Entrez gene	4130
UniProt	P78559 (UniProt - Evidence at protein level)
neXtProt	NX_P78559
Antibodypedia	MAP1A antibodies

PROTEIN BROWSER

MAP1A-001	MAP1A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP1A-001 ENSP00000300231 ENST00000300231	P78559 [Direct mapping] Microtubule-associated protein 1A MAP1A heavy chain MAP1 light chain LC2 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0001750 [photoreceptor outer segment] GO:0002230 [positive regulation of defense response to virus by host] GO:0003779 [actin binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0007026 [negative regulation of microtubule depolymerization] GO:0007605 [sensory perception of sound] GO:0008017 [microtubule binding] GO:0045494 [photoreceptor cell maintenance] GO:0097481 [neuronal postsynaptic density] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	2803 aa 305.5 kDa	No	0
MAP1A-002 ENSP00000371462 ENST00000382031	E9PGC8 [Direct mapping] Microtubule-associated protein 1A Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		3041 aa 331.3 kDa	No	0