Cell atlas - AKTIP - The Human Protein Atlas

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AKTIP

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	AKTIP
Gene description	AKT interacting protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	AKTIP (HGNC Symbol)
Synonyms	FLJ13258, FTS
Description	AKT interacting protein (HGNC Symbol)
Entrez gene summary	The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	53491040 - 53504411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166971 (version 83.38)
Entrez gene	64400
UniProt	Q9H8T0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8T0
Antibodypedia	AKTIP antibodies

PROTEIN BROWSER

AKTIP-001	AKTIP-002	AKTIP-003	AKTIP-005	AKTIP-006	AKTIP-007	AKTIP-008	AKTIP-009	AKTIP-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKTIP-001 ENSP00000378152 ENST00000394657	Q9H8T0 [Direct mapping] AKT-interacting protein A0A024R6T5 [Target identity:100%; Query identity:100%] Fused toes homolog (Mouse), isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0016567 [protein ubiquitination] GO:0030897 [HOPS complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032092 [positive regulation of protein binding] GO:0045022 [early endosome to late endosome transport] GO:0061630 [ubiquitin protein ligase activity] GO:0070695 [FHF complex] Show all	292 aa 33.1 kDa	No	0
AKTIP-002 ENSP00000455874 ENST00000570004	Q9H8T0 [Direct mapping] AKT-interacting protein A0A024R6T5 [Target identity:100%; Query identity:100%] Fused toes homolog (Mouse), isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0016567 [protein ubiquitination] GO:0030897 [HOPS complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032092 [positive regulation of protein binding] GO:0045022 [early endosome to late endosome transport] GO:0061630 [ubiquitin protein ligase activity] GO:0070695 [FHF complex] Show all	292 aa 33.1 kDa	No	0
AKTIP-003 ENSP00000300245 ENST00000300245	Q9H8T0 [Direct mapping] AKT-interacting protein A0A024R6S6 [Target identity:100%; Query identity:100%] Fused toes homolog (Mouse), isoform CRA_c Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0016567 [protein ubiquitination] GO:0030897 [HOPS complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032092 [positive regulation of protein binding] GO:0045022 [early endosome to late endosome transport] GO:0061630 [ubiquitin protein ligase activity] GO:0070695 [FHF complex] Show all	293 aa 33.3 kDa	No	0
AKTIP-005 ENSP00000456398 ENST00000564497	H3BRT7 [Direct mapping] AKT-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	14 aa 1.7 kDa	No	0
AKTIP-006 ENSP00000454269 ENST00000568022	H3BM79 [Direct mapping] AKT-interacting protein Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	249 aa 28 kDa	No	0
AKTIP-007 ENSP00000454771 ENST00000568596	H3BNB8 [Direct mapping] AKT-interacting protein Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	127 aa 14.2 kDa	No	0
AKTIP-008 ENSP00000458118 ENST00000565408	H3BVH0 [Direct mapping] AKT-interacting protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	136 aa 15.1 kDa	No	0
AKTIP-009 ENSP00000456922 ENST00000570041	H3BSX7 [Direct mapping] AKT-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	40 aa 4.5 kDa	No	0
AKTIP-010 ENSP00000456418 ENST00000563928	H3BRV2 [Direct mapping] AKT-interacting protein Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0061630 [ubiquitin protein ligase activity] Show all	150 aa 16.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.