Expression of CNPY4 in cancer - Summary - The Human Protein Atlas

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CNPY4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNPY4
Gene description	Canopy FGF signaling regulator 4
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA014166 , HPA025240
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014166	HPA025240

GENE INFORMATION
Gene name	CNPY4 (HGNC Symbol)
Synonyms	MGC40499, PRAT4B
Description	Canopy FGF signaling regulator 4 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100119613 - 100125511
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166997 (version 83.38)
Entrez gene	245812
UniProt	Q8N129 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N129
Antibodypedia	CNPY4 antibodies

PROTEIN BROWSER

CNPY4-001	CNPY4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNPY4-001 ENSP00000262932 ENST00000262932	Q8N129 [Direct mapping] Protein canopy homolog 4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] Show all	248 aa 28.3 kDa	Yes	0
CNPY4-005 ENSP00000488362 ENST00000483756		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.