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PDIA3

GENERAL INFORMATION

Gene name

 PDIA3

Gene description

 Protein disulfide isomerase family A, member 3

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues with highest levels in glandular epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA002645 , HPA003230 , CAB011199 , CAB015181
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDIA3 (HGNC Symbol)

Synonyms

 ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC

Description

 Protein disulfide isomerase family A, member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q15.3

Chromosome location (bp)

 43746392 - 43773279

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167004 (version 83.38)

Entrez gene

 2923

UniProt

 P30101 (UniProt - Evidence at protein level)

neXtProt

 NX_P30101

Antibodypedia

 PDIA3 antibodies

PROTEIN BROWSER
PDIA3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDIA3-001
ENSP00000300289
ENST00000300289
P30101 [Direct mapping]
Protein disulfide-isomerase A3
V9HVY3 [Target identity:100%; Query identity:100%]
Protein disulfide-isomerase
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0003756 [protein disulfide isomerase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004629 [phospholipase C activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006508 [proteolysis]
GO:0006606 [protein import into nucleus]
GO:0006621 [protein retention in ER lumen]
GO:0007165 [signal transduction]
GO:0009986 [cell surface]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016853 [isomerase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0042470 [melanosome]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043209 [myelin sheath]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
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 505 aa
56.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.