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NUDT21

GENERAL INFORMATION

Gene name

 NUDT21

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 21

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA019863
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019863

GENE INFORMATION

Gene name

 NUDT21 (HGNC Symbol)

Synonyms

 CFIM25, CPSF5

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 21 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q13

Chromosome location (bp)

 56429133 - 56452199

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167005 (version 83.38)

Entrez gene

 11051

UniProt

 O43809 (UniProt - Evidence at protein level)

neXtProt

 NX_O43809

Antibodypedia

 NUDT21 antibodies

PROTEIN BROWSER
NUDT21-001
NUDT21-003
NUDT21-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT21-001
ENSP00000300291
ENST00000300291
O43809 [Direct mapping]
Cleavage and polyadenylation specificity factor subunit 5
A0A024R6W2 [Target identity:100%; Query identity:100%]
Nudix (Nucleoside diphosphate linked moiety X)-type motif 21, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005849 [mRNA cleavage factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016787 [hydrolase activity]
GO:0017091 [AU-rich element binding]
GO:0031124 [mRNA 3'-end processing]
GO:0042382 [paraspeckles]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0044822 [poly(A) RNA binding]
GO:0051262 [protein tetramerization]
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 227 aa
26.2 kDa 		No 0
NUDT21-003
ENSP00000454790
ENST00000566340
H3BND3 [Direct mapping]
Cleavage and polyadenylation-specificity factor subunit 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003729 [mRNA binding]
GO:0005849 [mRNA cleavage factor complex]
GO:0006378 [mRNA polyadenylation]
GO:0016787 [hydrolase activity]
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 150 aa
17.2 kDa 		No 0
NUDT21-005
ENSP00000457942
ENST00000568822
H3BV41 [Direct mapping]
Cleavage and polyadenylation-specificity factor subunit 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0005849 [mRNA cleavage factor complex]
GO:0006378 [mRNA polyadenylation]
GO:0016787 [hydrolase activity]
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 71 aa
8.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.