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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

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Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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NKX3-1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NKX3-1

Gene description

NK3 homeobox 1

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (prostate)
GTEx:Group enriched (prostate, salivary gland)
FANTOM5:Tissue enhanced (prostate, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (prostate, salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate, tonsil)

GENE INFORMATION

Gene name

NKX3-1 (HGNC Symbol)

Synonyms

BAPX2, NKX3.1, NKX3A

Description

NK3 homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

Chromosome

8

Cytoband

p21.2

Chromosome location (bp)

23678693 - 23682927

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167034 (version 83.38)

Entrez gene

4824

UniProt

Q99801 (UniProt - Evidence at protein level)

neXtProt

NX_Q99801

Antibodypedia

NKX3-1 antibodies

PROTEIN BROWSER

NKX3-1-001
NKX3-1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NKX3-1-001
ENSP00000370253
ENST00000380871
Q99801 [Direct mapping]
Homeobox protein Nkx-3.1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0001047 [core promoter binding]
GO:0001655 [urogenital system development]
GO:0001656 [metanephros development]
GO:0001756 [somitogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0007431 [salivary gland development]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0030284 [estrogen receptor activity]
GO:0030295 [protein kinase activator activity]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0030850 [prostate gland development]
GO:0032147 [activation of protein kinase activity]
GO:0033574 [response to testosterone]
GO:0035690 [cellular response to drug]
GO:0035907 [dorsal aorta development]
GO:0042826 [histone deacetylase binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043491 [protein kinase B signaling]
GO:0043565 [sequence-specific DNA binding]
GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0060037 [pharyngeal system development]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071456 [cellular response to hypoxia]
GO:0071850 [mitotic cell cycle arrest]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0097162 [MADS box domain binding]
GO:2000836 [positive regulation of androgen secretion]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
234 aa
26.4 kDa
No 0
NKX3-1-004
ENSP00000429729
ENST00000523261
Q99801 [Direct mapping]
Homeobox protein Nkx-3.1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0007431 [salivary gland development]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0030284 [estrogen receptor activity]
GO:0030295 [protein kinase activator activity]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0032147 [activation of protein kinase activity]
GO:0033574 [response to testosterone]
GO:0035690 [cellular response to drug]
GO:0042826 [histone deacetylase binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043491 [protein kinase B signaling]
GO:0043565 [sequence-specific DNA binding]
GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0071456 [cellular response to hypoxia]
GO:0071850 [mitotic cell cycle arrest]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:2000836 [positive regulation of androgen secretion]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
159 aa
18.4 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.