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Most cancer tissues displayed moderate nuclear and cytoplasmic immunoreactivity. A few cases of melanomas, thyroid, ovarian and breast cancers were strongly stained. A majority of lymphomas and testicular cancers were weakly stained or negative.
GENE INFORMATION
Gene name
DUSP18 (HGNC Symbol)
Synonyms
DUSP20
Description
Dual specificity phosphatase 18 (HGNC Symbol)
Entrez gene summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]