Expression of MEI1 in cancer - Summary - The Human Protein Atlas

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MEI1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MEI1
Gene description	Meiotic double-stranded break formation protein 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer)
HPA (cell line):	Cell line enhanced (Karpas-707, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049240
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049240

GENE INFORMATION
Gene name	MEI1 (HGNC Symbol)
Synonyms	MGC40042, SPATA38
Description	Meiotic double-stranded break formation protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	41699499 - 41799456
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167077 (version 83.38)
Entrez gene	150365
UniProt	Q5TIA1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5TIA1
Antibodypedia	MEI1 antibodies

PROTEIN BROWSER

MEI1-001	MEI1-013	MEI1-014	MEI1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEI1-001 ENSP00000384115 ENST00000401548	Q5TIA1 [Direct mapping] Meiosis inhibitor protein 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005623 [cell] GO:0007126 [meiotic nuclear division] GO:0007127 [meiosis I] GO:0007141 [male meiosis I] GO:0007276 [gamete generation] GO:0007286 [spermatid development] GO:0045141 [meiotic telomere clustering] Show all	1274 aa 141.2 kDa	No	0
MEI1-013 ENSP00000385298 ENST00000403492	Q5TIA1 [Direct mapping] Meiosis inhibitor protein 1 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0007127 [meiosis I] Show all	238 aa 25.6 kDa	Yes	0
MEI1-014 ENSP00000410973 ENST00000423900	H0Y787 [Direct mapping] Meiosis inhibitor protein 1 Show all	Predicted intracellular proteins Show all		63 aa 6.5 kDa	No	0
MEI1-201 ENSP00000444225 ENST00000540833	F5GZT0 [Direct mapping] Meiosis inhibitor protein 1 Show all	Predicted intracellular proteins Show all	GO:0005488 [binding] Show all	506 aa 56.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.