Expression of DOLPP1 in cancer - Summary - The Human Protein Atlas

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DOLPP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DOLPP1
Gene description	Dolichyldiphosphatase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019179
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019179

GENE INFORMATION
Gene name	DOLPP1 (HGNC Symbol)
Synonyms	LSFR2
Description	Dolichyldiphosphatase 1 (HGNC Symbol)
Entrez gene summary	A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129081100 - 129090438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167130 (version 83.38)
Entrez gene	57171
UniProt	Q86YN1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86YN1
Antibodypedia	DOLPP1 antibodies

PROTEIN BROWSER

DOLPP1-001	DOLPP1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOLPP1-001 ENSP00000361625 ENST00000372546	Q86YN1 [Direct mapping] Dolichyldiphosphatase 1 A0A024R8B5 [Target identity:100%; Query identity:100%] Dolichyl pyrophosphate phosphatase 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047874 [dolichyldiphosphatase activity] Show all	238 aa 27 kDa	No	4
DOLPP1-003 ENSP00000384043 ENST00000406974	Q86YN1 [Direct mapping] Dolichyldiphosphatase 1 A0A0A6YYB0 [Direct mapping] Dolichyldiphosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047874 [dolichyldiphosphatase activity] Show all	195 aa 22.1 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.