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ENDOG

GENERAL INFORMATION

Gene name

 ENDOG

Gene description

 Endonuclease G

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA021335 , HPA021830
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA021335
HPA021830

GENE INFORMATION

Gene name

 ENDOG

Synonyms

Description

 Endonuclease G (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128818474 - 128822677

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167136 (version 83.38)

Entrez gene

 2021

UniProt

 Q14249 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14249

Antibodypedia

 ENDOG antibodies

PROTEIN BROWSER
ENDOG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENDOG-001
ENSP00000361725
ENST00000372642
Q14249 [Direct mapping]
Endonuclease G, mitochondrial
E5KNL5 [Target identity:100%; Query identity:100%]
Mitochondrial endonuclease G
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001701 [in utero embryonic development]
GO:0003676 [nucleic acid binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004536 [deoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0007568 [aging]
GO:0009612 [response to mechanical stimulus]
GO:0016787 [hydrolase activity]
GO:0032355 [response to estradiol]
GO:0034599 [cellular response to oxidative stress]
GO:0034612 [response to tumor necrosis factor]
GO:0036475 [neuron death in response to oxidative stress]
GO:0043065 [positive regulation of apoptotic process]
GO:0043204 [perikaryon]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0071277 [cellular response to calcium ion]
GO:0071333 [cellular response to glucose stimulus]
GO:0071456 [cellular response to hypoxia]
GO:1901300 [positive regulation of hydrogen peroxide-mediated programmed cell death]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
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 297 aa
32.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.