Expression of KATNAL2 in cancer - Summary - The Human Protein Atlas

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KATNAL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KATNAL2
Gene description	Katanin p60 subunit A-like 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear and nuclear membrane expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA040712 , HPA042029
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040712	HPA042029

GENE INFORMATION
Gene name	KATNAL2 (HGNC Symbol)
Synonyms	DKFZP667C165, MGC33211
Description	Katanin p60 subunit A-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	46917492 - 47102243
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167216 (version 83.38)
Entrez gene	83473
UniProt	Q8IYT4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IYT4
Antibodypedia	KATNAL2 antibodies

PROTEIN BROWSER

KATNAL2-001	KATNAL2-002	KATNAL2-006	KATNAL2-007	KATNAL2-008	KATNAL2-009	KATNAL2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KATNAL2-001 ENSP00000245121 ENST00000245121	Q8IYT4 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] GO:0051013 [microtubule severing] Show all	466 aa 52.8 kDa	No	0
KATNAL2-002 ENSP00000467488 ENST00000591522	K7EPQ6 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] Show all	154 aa 16.9 kDa	No	0
KATNAL2-006 ENSP00000464779 ENST00000588433	K7EIJ8 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] Show all	341 aa 38 kDa	No	0
KATNAL2-007 ENSP00000466302 ENST00000586198	K7EM02 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] Show all	128 aa 14 kDa	No	0
KATNAL2-008 ENSP00000467610 ENST00000592005	K7EQ00 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] Show all	105 aa 11.8 kDa	No	0
KATNAL2-009 ENSP00000466674 ENST00000585469	K7EMW1 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] Show all	222 aa 25.5 kDa	No	0
KATNAL2-010 ENSP00000348478 ENST00000356157	Q8IYT4 [Direct mapping] Katanin p60 ATPase-containing subunit A-like 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0008568 [microtubule-severing ATPase activity] GO:0031122 [cytoplasmic microtubule organization] GO:0051013 [microtubule severing] Show all	538 aa 61.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.