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IGF2

GENERAL INFORMATION

Gene name

 IGF2

Gene description

 Insulin-like growth factor 2

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, endometrial cancer, liver cancer, ovarian cancer, stomach cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in extravillous placental trophoblasts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA007556
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, endometrial cancer, liver cancer, ovarian cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA007556

GENE INFORMATION

Gene name

 IGF2 (HGNC Symbol)

Synonyms

 C11orf43, FLJ44734, IGF-II

Description

 Insulin-like growth factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 2129112 - 2141238

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167244 (version 83.38)

Entrez gene

 3481

UniProt

 P01344 (UniProt - Evidence at protein level)

neXtProt

 NX_P01344

Antibodypedia

 IGF2 antibodies

PROTEIN BROWSER
IGF2-001
IGF2-002
IGF2-003
IGF2-004
IGF2-005
IGF2-007
IGF2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGF2-001
ENSP00000414497
ENST00000416167
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 180 aa
20.1 kDa 		Yes 0
IGF2-002
ENSP00000370813
ENST00000381406
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 183 aa
20.5 kDa 		Yes 0
IGF2-003
ENSP00000370802
ENST00000381395
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 180 aa
20.1 kDa 		Yes 0
IGF2-004
ENSP00000370799
ENST00000381392
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 183 aa
20.5 kDa 		Yes 0
IGF2-005
ENSP00000402047
ENST00000418738
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 180 aa
20.1 kDa 		Yes 0
IGF2-007
ENSP00000391826
ENST00000434045
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007565 [female pregnancy]
GO:0007596 [blood coagulation]
GO:0007613 [memory]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0009314 [response to radiation]
GO:0009887 [organ morphogenesis]
GO:0014070 [response to organic cyclic compound]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031017 [exocrine pancreas development]
GO:0031093 [platelet alpha granule lumen]
GO:0031667 [response to nutrient levels]
GO:0032355 [response to estradiol]
GO:0035094 [response to nicotine]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042060 [wound healing]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042493 [response to drug]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045471 [response to ethanol]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045953 [negative regulation of natural killer cell mediated cytotoxicity]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051146 [striated muscle cell differentiation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 236 aa
26.3 kDa 		No 1
IGF2-009
ENSP00000370796
ENST00000381389
P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030546 [receptor activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
Show all
 180 aa
20.1 kDa 		Yes 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.