Expression of DPEP2 in cancer - Summary

GENERAL INFORMATION
Gene name	DPEP2
Gene description	Dipeptidase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous staining in several tissues, including subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA035644
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (unfavourable).
Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035644

GENE INFORMATION
Gene name	DPEP2
Synonyms
Description	Dipeptidase 2 (HGNC Symbol)
Entrez gene summary	DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67987394 - 68000586
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167261 (version 83.38)
Entrez gene	64174
UniProt	Q9H4A9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4A9
Antibodypedia	DPEP2 antibodies

PROTEIN BROWSER

DPEP2-001	DPEP2-002	DPEP2-006	DPEP2-007	DPEP2-008	DPEP2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPEP2-001 ENSP00000377430 ENST00000393847	Q9H4A9 [Direct mapping] Dipeptidase 2 A0A024R6Y5 [Target identity:100%; Query identity:100%] Dipeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	486 aa 53.4 kDa	Yes	1
DPEP2-002 ENSP00000458977 ENST00000572888	Q9H4A9 [Direct mapping] Dipeptidase 2 A0A024R6Y5 [Target identity:100%; Query identity:100%] Dipeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0008238 [exopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	486 aa 53.4 kDa	Yes	1
DPEP2-006 ENSP00000463604 ENST00000573808	J3QLL2 [Direct mapping] Dipeptidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	161 aa 17.8 kDa	Yes	0
DPEP2-007 ENSP00000460169 ENST00000572624	I3L348 [Direct mapping] Dipeptidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	137 aa 14.9 kDa	Yes	0
DPEP2-008 ENSP00000462652 ENST00000575510	J3KSU4 [Direct mapping] Dipeptidase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	123 aa 13.1 kDa	No	0
DPEP2-009 ENSP00000461250 ENST00000574865	I3L4H3 [Direct mapping] Dipeptidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0016805 [dipeptidase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	114 aa 12.4 kDa	Yes	0