Expression of CD3D in cancer - Summary - The Human Protein Atlas

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CD3D

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD3D
Gene description	CD3d molecule, delta (CD3-TCR complex)
Protein class	CD markers Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in a subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. CAB013055
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (unfavourable), cervical cancer (favourable), head and neck cancer (favourable), breast cancer (favourable) and urothelial cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Cervical cancer p<0.001 Head and neck cancer p<0.001 Breast cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB013055

GENE INFORMATION
Gene name	CD3D (HGNC Symbol)
Synonyms	T3D
Description	CD3d molecule, delta (CD3-TCR complex) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118338954 - 118342744
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167286 (version 83.38)
Entrez gene	915
UniProt	P04234 (UniProt - Evidence at protein level)
neXtProt	NX_P04234
Antibodypedia	CD3D antibodies

PROTEIN BROWSER

CD3D-001	CD3D-002	CD3D-003	CD3D-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD3D-001 ENSP00000300692 ENST00000300692	P04234 [Direct mapping] T-cell surface glycoprotein CD3 delta chain B0YIY4 [Target identity:100%; Query identity:100%] CD3d antigen, delta polypeptide (TiT3 complex), isoform CRA_a; T-cell surface glycoprotein CD3 delta chain; cDNA, FLJ92244, Homo sapiens CD3D antigen, delta polypeptide (TiT3 complex) (CD3D),mRNA Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030217 [T cell differentiation] GO:0031295 [T cell costimulation] GO:0042101 [T cell receptor complex] GO:0042105 [alpha-beta T cell receptor complex] GO:0045059 [positive thymic T cell selection] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0050776 [regulation of immune response] GO:0050852 [T cell receptor signaling pathway] Show all	171 aa 18.9 kDa	Yes	1
CD3D-002 ENSP00000437335 ENST00000529594	E9PMT5 [Direct mapping] CD3 delta; T-cell surface glycoprotein CD3 delta chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	98 aa 10.5 kDa	Yes	1
CD3D-003 ENSP00000376622 ENST00000392884	P04234 [Direct mapping] T-cell surface glycoprotein CD3 delta chain Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030217 [T cell differentiation] GO:0031295 [T cell costimulation] GO:0042101 [T cell receptor complex] GO:0045059 [positive thymic T cell selection] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0050776 [regulation of immune response] GO:0050852 [T cell receptor signaling pathway] Show all	127 aa 14.5 kDa	Yes	0
CD3D-005 ENSP00000434794 ENST00000534687	H0YE18 [Direct mapping] T-cell surface glycoprotein CD3 delta chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] Show all	132 aa 15 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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