Cell atlas - STIM1 - The Human Protein Atlas

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STIM1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	STIM1
Gene description	Stromal interaction molecule 1
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA011088 , HPA012123
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011088	A-431	Endoplasmic reticulum
	HPA011088	U-251 MG	Endoplasmic reticulum
	HPA012123	A-431	Endoplasmic reticulum
	HPA012123	A549	Endoplasmic reticulum
	HPA012123	U-2 OS	No staining

GENE INFORMATION
Gene name	STIM1 (HGNC Symbol)
Synonyms	D11S4896E, GOK
Description	Stromal interaction molecule 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	3854527 - 4093210
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167323 (version 83.38)
Entrez gene	6786
UniProt	Q13586 (UniProt - Evidence at protein level)
neXtProt	NX_Q13586
Antibodypedia	STIM1 antibodies

PROTEIN BROWSER

STIM1-001	STIM1-002	STIM1-003	STIM1-004	STIM1-005	STIM1-006	STIM1-007	STIM1-010	STIM1-015	STIM1-016	STIM1-017	STIM1-018	STIM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STIM1-001 ENSP00000300737 ENST00000300737	Q13586 [Direct mapping] Stromal interaction molecule 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005874 [microtubule] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0007596 [blood coagulation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0042802 [identical protein binding] GO:0051010 [microtubule plus-end binding] GO:0051924 [regulation of calcium ion transport] GO:0070166 [enamel mineralization] Show all	685 aa 77.4 kDa	Yes	1
STIM1-002 ENSP00000436208 ENST00000527651	Q13586 [Direct mapping] Stromal interaction molecule 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005874 [microtubule] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0007596 [blood coagulation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0042802 [identical protein binding] GO:0051010 [microtubule plus-end binding] GO:0051924 [regulation of calcium ion transport] GO:0070166 [enamel mineralization] Show all	540 aa 62.1 kDa	Yes	1
STIM1-003 ENSP00000434767 ENST00000533977	E9PNJ4 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005783 [endoplasmic reticulum] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	512 aa 57.6 kDa	No	1
STIM1-004 ENSP00000432210 ENST00000525403	E9PRZ7 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	110 aa 12.9 kDa	No	0
STIM1-005 ENSP00000433949 ENST00000532919	E9PIQ8 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	139 aa 16.2 kDa	No	0
STIM1-006 ENSP00000432383 ENST00000532990	E9PR07 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	67 aa 7.9 kDa	No	0
STIM1-007 ENSP00000431191 ENST00000525055	E9PMB4 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	83 aa 9.9 kDa	No	0
STIM1-010 ENSP00000433266 ENST00000526596	H0YDB2 [Direct mapping] Stromal interaction molecule 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	405 aa 45.3 kDa	No	0
STIM1-015 ENSP00000434848 ENST00000532610	E9PN27 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	133 aa 15.4 kDa	No	0
STIM1-016 ENSP00000432378 ENST00000528656	E9PR09 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	117 aa 13.7 kDa	No	0
STIM1-017 ENSP00000434200 ENST00000524822	E9PRE4 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	54 aa 6.3 kDa	No	0
STIM1-018 ENSP00000431878 ENST00000530554	E9PJ19 [Direct mapping] Stromal interaction molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	81 aa 9.7 kDa	No	0
STIM1-201 ENSP00000478059 ENST00000616714	G0XQ39 [Direct mapping] STIM1L; Stromal interaction molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002115 [store-operated calcium entry] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0006812 [cation transport] GO:0014902 [myotube differentiation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032237 [activation of store-operated calcium channel activity] GO:0043234 [protein complex] Show all	791 aa 88.6 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.