Fields »
ABOUT
HELP
BLOG
STIM1

GENERAL INFORMATION

Gene name

 STIM1

Gene description

 Stromal interaction molecule 1

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA011088 , HPA012123 , CAB037128 , CAB037288
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA011088
HPA012123
CAB037128
CAB037288

GENE INFORMATION

Gene name

 STIM1 (HGNC Symbol)

Synonyms

 D11S4896E, GOK

Description

 Stromal interaction molecule 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 3854527 - 4093210

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167323 (version 83.38)

Entrez gene

 6786

UniProt

 Q13586 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13586

Antibodypedia

 STIM1 antibodies

PROTEIN BROWSER
«
STIM1-001
STIM1-002
STIM1-003
STIM1-004
STIM1-005
STIM1-006
STIM1-007
STIM1-010
STIM1-015
STIM1-016
STIM1-017
STIM1-018
STIM1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STIM1-001
ENSP00000300737
ENST00000300737
Q13586 [Direct mapping]
Stromal interaction molecule 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005874 [microtubule]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0051010 [microtubule plus-end binding]
GO:0051924 [regulation of calcium ion transport]
GO:0070166 [enamel mineralization]
Show all
 685 aa
77.4 kDa 		Yes 1
STIM1-002
ENSP00000436208
ENST00000527651
Q13586 [Direct mapping]
Stromal interaction molecule 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005874 [microtubule]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0051010 [microtubule plus-end binding]
GO:0051924 [regulation of calcium ion transport]
GO:0070166 [enamel mineralization]
Show all
 540 aa
62.1 kDa 		Yes 1
STIM1-003
ENSP00000434767
ENST00000533977
E9PNJ4 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005783 [endoplasmic reticulum]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 512 aa
57.6 kDa 		No 1
STIM1-004
ENSP00000432210
ENST00000525403
E9PRZ7 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 110 aa
12.9 kDa 		No 0
STIM1-005
ENSP00000433949
ENST00000532919
E9PIQ8 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 139 aa
16.2 kDa 		No 0
STIM1-006
ENSP00000432383
ENST00000532990
E9PR07 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 67 aa
7.9 kDa 		No 0
STIM1-007
ENSP00000431191
ENST00000525055
E9PMB4 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 83 aa
9.9 kDa 		No 0
STIM1-010
ENSP00000433266
ENST00000526596
H0YDB2 [Direct mapping]
Stromal interaction molecule 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 405 aa
45.3 kDa 		No 0
STIM1-015
ENSP00000434848
ENST00000532610
E9PN27 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 133 aa
15.4 kDa 		No 0
STIM1-016
ENSP00000432378
ENST00000528656
E9PR09 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 117 aa
13.7 kDa 		No 0
STIM1-017
ENSP00000434200
ENST00000524822
E9PRE4 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 54 aa
6.3 kDa 		No 0
STIM1-018
ENSP00000431878
ENST00000530554
E9PJ19 [Direct mapping]
Stromal interaction molecule 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
Show all
 81 aa
9.7 kDa 		No 0
STIM1-201
ENSP00000478059
ENST00000616714
G0XQ39 [Direct mapping]
STIM1L; Stromal interaction molecule 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002115 [store-operated calcium entry]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0006812 [cation transport]
GO:0014902 [myotube differentiation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0043234 [protein complex]
Show all
 791 aa
88.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.