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RRM1

GENERAL INFORMATION

Gene name

 RRM1

Gene description

 Ribonucleotide reductase M1

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression of glandular cells and hematopoetic cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA057265 , HPA064297 , CAB022093
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RRM1

Synonyms

Description

 Ribonucleotide reductase M1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 4094707 - 4138876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167325 (version 83.38)

Entrez gene

 6240

UniProt

 P23921 (UniProt - Evidence at protein level)

neXtProt

 NX_P23921

Antibodypedia

 RRM1 antibodies

PROTEIN BROWSER
RRM1-001
RRM1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRM1-001
ENSP00000300738
ENST00000300738
P23921 [Direct mapping]
Ribonucleoside-diphosphate reductase large subunit
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006260 [DNA replication]
GO:0008584 [male gonad development]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0010212 [response to ionizing radiation]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0017076 [purine nucleotide binding]
GO:0021846 [cell proliferation in forebrain]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0044281 [small molecule metabolic process]
GO:0051259 [protein oligomerization]
GO:0051290 [protein heterotetramerization]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0060041 [retina development in camera-type eye]
GO:0070062 [extracellular exosome]
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 792 aa
90.1 kDa 		No 0
RRM1-005
ENSP00000431464
ENST00000534285
E9PL69 [Direct mapping]
Ribonucleoside-diphosphate reductase large subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0055114 [oxidation-reduction process]
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 570 aa
64.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.