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Group enriched (endometrial cancer, prostate cancer)
HPA (cell line):
Not detected
HPA (normal tissue):
Tissue enriched (endometrium)
Protein evidence
Evidence at transcript level
ANTIBODY IHC RELIABILITY
Reliability score
Pending cancer tissue analysis.
PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all
RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (endometrial cancer, prostate cancer)
PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY
GENE INFORMATION
Gene name
MMP26 (HGNC Symbol)
Synonyms
endometase, MGC126590, MGC126592
Description
Matrix metallopeptidase 26 (HGNC Symbol)
Entrez gene summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. [provided by RefSeq, Jul 2008]
