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LPO

GENERAL INFORMATION

Gene name

 LPO

Gene description

 Lactoperoxidase

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (salivary gland)
GTEx:Tissue enriched (salivary gland)
FANTOM5:Tissue enriched (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in salivary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA028688
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 LPO (HGNC Symbol)

Synonyms

 SPO

Description

 Lactoperoxidase (HGNC Symbol)

Entrez gene summary

 This gene encodes an oxidoreductase secreted from salivary, mammary, and other mucosal glands that functions as a natural antibacterial agent. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 58218548 - 58268518

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167419 (version 83.38)

Entrez gene

 4025

UniProt

 P22079 (UniProt - Evidence at protein level)

neXtProt

 NX_P22079

Antibodypedia

 LPO antibodies

PROTEIN BROWSER
LPO-001
LPO-002
LPO-006
LPO-010
LPO-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPO-001
ENSP00000262290
ENST00000262290
P22079 [Direct mapping]
Lactoperoxidase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0004601 [peroxidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006979 [response to oxidative stress]
GO:0016323 [basolateral plasma membrane]
GO:0018969 [thiocyanate metabolic process]
GO:0020037 [heme binding]
GO:0036393 [thiocyanate peroxidase activity]
GO:0042742 [defense response to bacterium]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 712 aa
80.3 kDa 		Yes 0
LPO-002
ENSP00000445344
ENST00000543544
F5H386 [Direct mapping]
Lactoperoxidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0006979 [response to oxidative stress]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 653 aa
74 kDa 		No 0
LPO-006
ENSP00000464636
ENST00000582328
P22079 [Direct mapping]
Lactoperoxidase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0004601 [peroxidase activity]
GO:0005615 [extracellular space]
GO:0006979 [response to oxidative stress]
GO:0016323 [basolateral plasma membrane]
GO:0018969 [thiocyanate metabolic process]
GO:0020037 [heme binding]
GO:0036393 [thiocyanate peroxidase activity]
GO:0042742 [defense response to bacterium]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 629 aa
71 kDa 		Yes 0
LPO-010
ENSP00000464643
ENST00000581008
J3QSD8 [Direct mapping]
Lactoperoxidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0006979 [response to oxidative stress]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 123 aa
13.5 kDa 		No 0
LPO-201
ENSP00000400245
ENST00000421678
P22079 [Direct mapping]
Lactoperoxidase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0004601 [peroxidase activity]
GO:0005615 [extracellular space]
GO:0006979 [response to oxidative stress]
GO:0016323 [basolateral plasma membrane]
GO:0018969 [thiocyanate metabolic process]
GO:0020037 [heme binding]
GO:0036393 [thiocyanate peroxidase activity]
GO:0042742 [defense response to bacterium]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 629 aa
71 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.