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GATAD2A

GENERAL INFORMATION

Gene name

 GATAD2A

Gene description

 GATA zinc finger domain containing 2A

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006759 , HPA024373
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006759
HPA024373

GENE INFORMATION

Gene name

 GATAD2A (HGNC Symbol)

Synonyms

 p66alpha

Description

 GATA zinc finger domain containing 2A (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 19385826 - 19508931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167491 (version 83.38)

Entrez gene

 54815

UniProt

 Q86YP4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86YP4

Antibodypedia

 GATAD2A antibodies

PROTEIN BROWSER
GATAD2A-001
GATAD2A-002
GATAD2A-004
GATAD2A-006
GATAD2A-007
GATAD2A-008
GATAD2A-009
GATAD2A-013
GATAD2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GATAD2A-001
ENSP00000351552
ENST00000358713
Q86YP4 [Direct mapping]
Transcriptional repressor p66-alpha
A0A024R7K7 [Target identity:100%; Query identity:100%]
GATA zinc finger domain containing 2A, isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016581 [NuRD complex]
GO:0016607 [nuclear speck]
GO:0030674 [protein binding, bridging]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 633 aa
68.1 kDa 		No 0
GATAD2A-002
ENSP00000384899
ENST00000404158
Q86YP4 [Direct mapping]
Transcriptional repressor p66-alpha
A0A024R7M6 [Target identity:100%; Query identity:100%]
GATA zinc finger domain containing 2A, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001701 [in utero embryonic development]
GO:0001842 [neural fold formation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010172 [embryonic body morphogenesis]
GO:0012501 [programmed cell death]
GO:0016581 [NuRD complex]
GO:0016607 [nuclear speck]
GO:0021506 [anterior neuropore closure]
GO:0030674 [protein binding, bridging]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 634 aa
68.1 kDa 		No 0
GATAD2A-004
ENSP00000477171
ENST00000494516
V9GYX5 [Direct mapping]
Transcriptional repressor p66-alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 77 aa
8.3 kDa 		No 0
GATAD2A-006
ENSP00000404212
ENST00000457895
C9JHD7 [Direct mapping]
Transcriptional repressor p66-alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 166 aa
18.4 kDa 		No 0
GATAD2A-007
ENSP00000390495
ENST00000432704
C9JGN4 [Direct mapping]
Transcriptional repressor p66-alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 139 aa
15 kDa 		No 0
GATAD2A-008
ENSP00000414252
ENST00000429242
C9JMI3 [Direct mapping]
Transcriptional repressor p66-alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 126 aa
13.6 kDa 		No 0
GATAD2A-009
ENSP00000407293
ENST00000444839
C9JVY3 [Direct mapping]
Transcriptional repressor p66-alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 93 aa
10.1 kDa 		No 0
GATAD2A-013
ENSP00000403703
ENST00000417582
C9JJK9 [Direct mapping]
Transcriptional repressor p66-alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 177 aa
19.6 kDa 		No 0
GATAD2A-201
ENSP00000353463
ENST00000360315
Q86YP4 [Direct mapping]
Transcriptional repressor p66-alpha
A0A024R7K7 [Target identity:100%; Query identity:100%]
GATA zinc finger domain containing 2A, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006306 [DNA methylation]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016581 [NuRD complex]
GO:0016607 [nuclear speck]
GO:0030674 [protein binding, bridging]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 633 aa
68.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.