Expression of MVD in cancer - Summary - The Human Protein Atlas

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MVD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MVD
Gene description	Mevalonate (diphospho) decarboxylase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA041404 , HPA048250
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041404	HPA048250

GENE INFORMATION
Gene name	MVD (HGNC Symbol)
Synonyms	MPD
Description	Mevalonate (diphospho) decarboxylase (HGNC Symbol)
Entrez gene summary	The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.2
Chromosome location (bp)	88651935 - 88663161
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167508 (version 83.38)
Entrez gene	4597
UniProt	P53602 (UniProt - Evidence at protein level)
neXtProt	NX_P53602
Antibodypedia	MVD antibodies

PROTEIN BROWSER

MVD-001	MVD-007	MVD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MVD-001 ENSP00000301012 ENST00000301012	P53602 [Direct mapping] Diphosphomevalonate decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004163 [diphosphomevalonate decarboxylase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008284 [positive regulation of cell proliferation] GO:0008299 [isoprenoid biosynthetic process] GO:0016831 [carboxy-lyase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019287 [isopentenyl diphosphate biosynthetic process, mevalonate pathway] GO:0030544 [Hsp70 protein binding] GO:0042803 [protein homodimerization activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] Show all	400 aa 43.4 kDa	No	0
MVD-007 ENSP00000455131 ENST00000569177	H3BP35 [Direct mapping] Diphosphomevalonate decarboxylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008299 [isoprenoid biosynthetic process] GO:0016831 [carboxy-lyase activity] Show all	271 aa 29.4 kDa	No	1
MVD-201 ENSP00000479264 ENST00000620002	A0A087WV85 [Direct mapping] Diphosphomevalonate decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008299 [isoprenoid biosynthetic process] GO:0016831 [carboxy-lyase activity] Show all	138 aa 14.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.