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CDT1

GENERAL INFORMATION

Gene name

 CDT1

Gene description

 Chromatin licensing and DNA replication factor 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General expression in nucleus

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA017224
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017224

GENE INFORMATION

Gene name

 CDT1 (HGNC Symbol)

Synonyms

 DUP, RIS2

Description

 Chromatin licensing and DNA replication factor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

Chromosome

 16

Cytoband

 q24.3

Chromosome location (bp)

 88803213 - 88809258

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167513 (version 83.38)

Entrez gene

 81620

UniProt

 Q9H211 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H211

Antibodypedia

 CDT1 antibodies

PROTEIN BROWSER
CDT1-001
CDT1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDT1-001
ENSP00000301019
ENST00000301019
Q9H211 [Direct mapping]
DNA replication factor Cdt1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000076 [DNA replication checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0030174 [regulation of DNA-dependent DNA replication initiation]
GO:0033262 [regulation of nuclear cell cycle DNA replication]
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 546 aa
60.4 kDa 		No 0
CDT1-002
ENSP00000456926
ENST00000569140
H3BSY1 [Direct mapping]
DNA replication factor Cdt1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 190 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.