Expression of LALBA in cancer - Summary

GENERAL INFORMATION
Gene name	LALBA
Gene description	Lactalbumin, alpha-
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in glandular and ductal cells in lactating breast. Additional plasma positivity.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 3 antibodies. HPA029855 , HPA029856 , CAB026343
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029855	HPA029856	CAB026343

GENE INFORMATION
Gene name	LALBA (HGNC Symbol)
Synonyms	LYZL7
Description	Lactalbumin, alpha- (HGNC Symbol)
Entrez gene summary	This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.11
Chromosome location (bp)	48567684 - 48570066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167531 (version 83.38)
Entrez gene	3906
UniProt	P00709 (UniProt - Evidence at protein level)
neXtProt	NX_P00709
Antibodypedia	LALBA antibodies

PROTEIN BROWSER

LALBA-001	LALBA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LALBA-001 ENSP00000301046 ENST00000301046	P00709 [Direct mapping] Alpha-lactalbumin A0A080YV01 [Target identity:100%; Query identity:100%] Lysozyme G Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000139 [Golgi membrane] GO:0004461 [lactose synthase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0005989 [lactose biosynthetic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0042742 [defense response to bacterium] GO:0044281 [small molecule metabolic process] Show all	142 aa 16.2 kDa	Yes	0
LALBA-002 ENSP00000449780 ENST00000549817	F8VWU1 [Direct mapping] Alpha-lactalbumin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004461 [lactose synthase activity] GO:0005509 [calcium ion binding] GO:0005989 [lactose biosynthetic process] Show all	123 aa 14 kDa	Yes	0