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CACNB3

GENERAL INFORMATION

Gene name

 CACNB3

Gene description

 Calcium channel, voltage-dependent, beta 3 subunit

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 CACNB3 (HGNC Symbol)

Synonyms

 CACNLB3

Description

 Calcium channel, voltage-dependent, beta 3 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 48813794 - 48828941

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167535 (version 83.38)

Entrez gene

 784

UniProt

 P54284 (UniProt - Evidence at protein level)

neXtProt

 NX_P54284

Antibodypedia

 CACNB3 antibodies

PROTEIN BROWSER
CACNB3-001
CACNB3-002
CACNB3-004
CACNB3-006
CACNB3-015
CACNB3-017
CACNB3-018
CACNB3-022
CACNB3-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNB3-001
ENSP00000301050
ENST00000301050
P54284 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 484 aa
54.5 kDa 		No 0
CACNB3-002
ENSP00000445495
ENST00000540990
P54284 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 471 aa
53.1 kDa 		No 0
CACNB3-004
ENSP00000444160
ENST00000536187
P54284 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 483 aa
54.4 kDa 		No 0
CACNB3-006
ENSP00000446529
ENST00000547392
F8VNV8 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 457 aa
51.6 kDa 		No 0
CACNB3-015
ENSP00000448137
ENST00000547818
F8VUW8 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 122 aa
13.5 kDa 		No 0
CACNB3-017
ENSP00000449497
ENST00000548279
F8VWK1 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 144 aa
16.2 kDa 		No 0
CACNB3-018
ENSP00000448304
ENST00000547230
P54284 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0016020 [membrane]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 443 aa
50 kDa 		No 0
CACNB3-022
ENSP00000447261
ENST00000550190
H0YHK1 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 84 aa
9.2 kDa 		No 0
CACNB3-024
ENSP00000448074
ENST00000550064
F8VU10 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 55 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.