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TUBA1A

GENERAL INFORMATION

Gene name

 TUBA1A

Gene description

 Tubulin, alpha 1a

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA039247 , HPA043684 , HPA063394 , CAB008686
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039247
HPA043684
HPA063394
CAB008686

GENE INFORMATION

Gene name

 TUBA1A (HGNC Symbol)

Synonyms

 B-ALPHA-1, FLJ25113, TUBA3

Description

 Tubulin, alpha 1a (HGNC Symbol)

Entrez gene summary

 Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49184796 - 49189324

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167552 (version 83.38)

Entrez gene

 7846

UniProt

 Q71U36 (UniProt - Evidence at protein level)

neXtProt

 NX_Q71U36

Antibodypedia

 TUBA1A antibodies

PROTEIN BROWSER
TUBA1A-001
TUBA1A-002
TUBA1A-006
TUBA1A-008
TUBA1A-009
TUBA1A-010
TUBA1A-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBA1A-001
ENSP00000301071
ENST00000301071
Q71U36 [Direct mapping]
Tubulin alpha-1A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0019904 [protein domain specific binding]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0051301 [cell division]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
Show all
 451 aa
50.1 kDa 		No 0
TUBA1A-002
ENSP00000439020
ENST00000295766
Q71U36 [Direct mapping]
Tubulin alpha-1A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0051301 [cell division]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
Show all
 451 aa
50.1 kDa 		No 0
TUBA1A-006
ENSP00000446637
ENST00000550767
Q71U36 [Direct mapping]
Tubulin alpha-1A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0051301 [cell division]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
Show all
 416 aa
46.3 kDa 		No 0
TUBA1A-008
ENSP00000448725
ENST00000552924
F8VRZ4 [Direct mapping]
Tubulin alpha-1A chain
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 112 aa
12.2 kDa 		No 0
TUBA1A-009
ENSP00000450268
ENST00000547939
F8VQQ4 [Direct mapping]
Tubulin alpha-1A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 219 aa
24.2 kDa 		No 0
TUBA1A-010
ENSP00000449016
ENST00000550811
F8VXZ7 [Direct mapping]
Tubulin alpha-1A chain
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
Show all
 26 aa
2.7 kDa 		No 0
TUBA1A-011
ENSP00000446613
ENST00000546918
F8W0F6 [Direct mapping]
Tubulin alpha-1A chain
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 231 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.