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TUBA1C

GENERAL INFORMATION

Gene name

 TUBA1C

Gene description

 Tubulin, alpha 1c

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA039247 , HPA043684 , HPA063394
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), pancreatic cancer (unfavourable), colorectal cancer (favourable), breast cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
Colorectal cancer p<0.001
Breast cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA039247
HPA043684
HPA063394

GENE INFORMATION

Gene name

 TUBA1C (HGNC Symbol)

Synonyms

 bcm948, MGC10851, MGC14580, TUBA6

Description

 Tubulin, alpha 1c (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49188736 - 49274603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167553 (version 83.38)

Entrez gene

 84790

UniProt

 Q9BQE3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQE3

Antibodypedia

 TUBA1C antibodies

PROTEIN BROWSER
TUBA1C-001
TUBA1C-002
TUBA1C-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBA1C-001
ENSP00000301072
ENST00000301072
Q9BQE3 [Direct mapping]
Tubulin alpha-1C chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0031982 [vesicle]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0051301 [cell division]
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 449 aa
49.9 kDa 		No 0
TUBA1C-002
ENSP00000443475
ENST00000541364
F5H5D3 [Direct mapping]
Tubulin alpha-1C chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
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 519 aa
57.7 kDa 		No 0
TUBA1C-006
ENSP00000448211
ENST00000549183
F8VS66 [Direct mapping]
Tubulin alpha-1C chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 130 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.