Expression of PPP1R14A in cancer - Summary - The Human Protein Atlas

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PPP1R14A

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPP1R14A
Gene description	Protein phosphatase 1, regulatory (inhibitor) subunit 14A
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A549, EFO-21, K-562)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues and in blood vessles.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA042097 , CAB005044 , CAB009803
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042097	CAB005044	CAB009803

GENE INFORMATION
Gene name	PPP1R14A (HGNC Symbol)
Synonyms	CPI-17, PPP1INL
Description	Protein phosphatase 1, regulatory (inhibitor) subunit 14A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38251237 - 38256591
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167641 (version 83.38)
Entrez gene	94274
UniProt	Q96A00 (UniProt - Evidence at protein level)
neXtProt	NX_Q96A00
Antibodypedia	PPP1R14A antibodies

PROTEIN BROWSER

PPP1R14A-001	PPP1R14A-002	PPP1R14A-003	PPP1R14A-004	PPP1R14A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R14A-001 ENSP00000301242 ENST00000301242	Q96A00 [Direct mapping] Protein phosphatase 1 regulatory subunit 14A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0042325 [regulation of phosphorylation] GO:0043086 [negative regulation of catalytic activity] Show all	147 aa 16.7 kDa	No	0
PPP1R14A-002 ENSP00000301243 ENST00000347262	Q96A00 [Direct mapping] Protein phosphatase 1 regulatory subunit 14A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0042325 [regulation of phosphorylation] GO:0043086 [negative regulation of catalytic activity] Show all	120 aa 13.5 kDa	No	0
PPP1R14A-003 ENSP00000465104 ENST00000591585	K7EJB8 [Direct mapping] Protein phosphatase 1 regulatory subunit 14A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0042325 [regulation of phosphorylation] Show all	121 aa 13.9 kDa	No	0
PPP1R14A-004 ENSP00000465811 ENST00000587515	A0A0B4J2A3 [Direct mapping] Protein phosphatase 1 regulatory subunit 14A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0042325 [regulation of phosphorylation] Show all	77 aa 8.7 kDa	No	0
PPP1R14A-005 ENSP00000466572 ENST00000591291	K7EMN0 [Direct mapping] Protein phosphatase 1 regulatory subunit 14A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0042325 [regulation of phosphorylation] Show all	123 aa 13.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.