Expression of SPINT2 in cancer - Summary - The Human Protein Atlas

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SPINT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPINT2
Gene description	Serine peptidase inhibitor, Kunitz type, 2
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, CAPAN-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA011101 , CAB018969
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA011101	CAB018969

GENE INFORMATION
Gene name	SPINT2 (HGNC Symbol)
Synonyms	HAI-2, Kop
Description	Serine peptidase inhibitor, Kunitz type, 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38244035 - 38292614
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167642 (version 83.38)
Entrez gene	10653
UniProt	O43291 (UniProt - Evidence at protein level)
neXtProt	NX_O43291
Antibodypedia	SPINT2 antibodies

PROTEIN BROWSER

SPINT2-001	SPINT2-002	SPINT2-004	SPINT2-005	SPINT2-006	SPINT2-009	SPINT2-010	SPINT2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINT2-001 ENSP00000301244 ENST00000301244	O43291 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0007163 [establishment or maintenance of cell polarity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] GO:0022408 [negative regulation of cell-cell adhesion] GO:0060672 [epithelial cell morphogenesis involved in placental branching] GO:0071711 [basement membrane organization] GO:0071773 [cellular response to BMP stimulus] GO:2000146 [negative regulation of cell motility] GO:2000178 [negative regulation of neural precursor cell proliferation] Show all	252 aa 28.2 kDa	Yes	1
SPINT2-002 ENSP00000389788 ENST00000454580	O43291 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] GO:0022408 [negative regulation of cell-cell adhesion] GO:2000146 [negative regulation of cell motility] Show all	195 aa 21.8 kDa	Yes	1
SPINT2-004 ENSP00000466407 ENST00000587090	K7EM91 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] Show all	202 aa 22.8 kDa	No	1
SPINT2-005 ENSP00000465561 ENST00000592007	K7EKC8 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	62 aa 6.7 kDa	No	0
SPINT2-006 ENSP00000465721 ENST00000587516	K7EKQ0 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	175 aa 19.8 kDa	Yes	0
SPINT2-009 ENSP00000468728 ENST00000590738	K7ESI5 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005634 [nucleus] GO:0010951 [negative regulation of endopeptidase activity] Show all	130 aa 14.7 kDa	No	0
SPINT2-010 ENSP00000468519 ENST00000587334	K7ES27 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	106 aa 11.2 kDa	No	1
SPINT2-011 ENSP00000465301 ENST00000590510	K7EJS4 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	52 aa 5.8 kDa	No	0

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